Interventional Treatments for Mood and Anxiety Disorders

Presented by Kyle Lapidus, MD, Ph.D.

Interventional treatments show increasing promise in the treatment of psychiatric disorders, particularly treatment resistant depression (TRD) and obsessive-compulsive disorder (OCD). Development of tools and techniques including deep brain stimulation (DBS), transcranial magnetic stimulation (TMS), and electroconvulsive therapy (ECT), as well as novel medications may yield additional options for patients who fail to respond to standard pharmaceutical and psychotherapeutic treatments.  This presentation reviews the motivation for and use of these treatments. We provide a brief description of the illnesses followed by discussion of the circuit models thought to underlie these disorders. These circuits provide targets for intervention. Using understanding of these basic mechanisms, we discuss mechanisms and techniques for novel interventional treatments. The discussion focuses on novel pharmacological tools, particularly ketamine/esketamine and brexanolone, as well as neuromodulatory treatments: DBS, TMS, and ECT.

This workshop was recorded on March 3, 2023.